A pastiche of Spanish colonial sophistication, artistic savoir faire and the Southwest's signature grit, the desert city of Santa Fe soaks visitors in creative culture, myriad music venues, famed restaurants and an incredibly gay-friendly atmosphere. Brimming with history -- the city was officially founded in 1610 -- and sophistication, such as the nation's third largest art market, the so-called City Different is an incomparable destination known to transform tourists into locals.